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2019-06-22 at 08:00AM UTC #280428
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Overall survival was similar for anastrozole and tamoxifen (hazard ratio 0·97, arimidex loss of appetite arimidex once a week arimidex vs tamoxifen pct arimidex and osteoporosis 95% CI 0·85–1·12, p=0·7); a 12% reduction in deaths from breast cancer in the anastrozole group was not significant (0·88, 0·74–1·05; p=0·2) .
However, since the arimidex trial population had a relatively good prognosis (5695 [61%] of patients were lymph-node-negative and 5959 [64%] had tumours 2 cm or smaller in diameter), it is too early to expect a difference in survival .
5 The significant reductions in recurrence and distant recurrence associated with anastrozole arimidex strongly suggest that a reduction in deaths from breast cancer will eventually be seen . For example, it took anastrozole five years anastrozole vs nolvadex anastrozole tablets uses anastrozole and osteoporosis at least 7 years to show a significant survival advantage for tamoxifen versus placebo in previous adjuvant studies .
Since almost all patients have completed their scheduled 5 years of therapy, the safety and arimidex tolerability data during treatment can be deemed final .
Withdrawals due to adverse events were significantly less common with anastrozole (344, 11·1%) arimidex results arimidex queda de cabelo anastrozole reduce gyno arimidex queda de cabelo than with tamoxifen (442, 14·3%; p=0·0002) .
Drug-related serious adverse events were also significantly less common with anastrozole (146, 4·7%) than arimidex with tamoxifen (271, 9·0%; p<0·0001) .

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