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2019-06-29 at 11:26AM UTC #281101
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Limb Ischemia, Necrosis, and Gangrene in Patients pt range on coumadin too much coumadin in your system coumadin diarrhea coumadin clinic maryland how with HIT Do not use COUMADIN as initial therapy in patients with heparin-induced thrombocytopenia (HIT) and with heparin-induced thrombocytopenia with thrombosis syndrome (HITTS) .
Cases of limb ischemia, necrosis, and gangrene have occurred in patients with HIT and HITTS when heparin treatment was discontinued coumadin and warfarin therapy was started or continued .
In some patients, sequelae have included coumadin amputation of the involved area and/or death .
Treatment with COUMADIN may be considered after the coumadin platelet count has normalized .
Use in Pregnant Women with Mechanical Heart Valves COUMADIN coumadin can cause fetal harm when administered to a pregnant woman .
While COUMADIN is contraindicated during pregnancy, the potential benefits of coumadin using COUMADIN may outweigh the risks for pregnant women with mechanical heart valves at high risk of thromboembolism .
In those individual situations, the decision to initiate or continue COUMADIN should be reviewed with the patient, taking into consideration the specific risks and benefits pertaining to the individual patient’s medical situation, coumadin as well as the most current medical guidelines .
COUMADIN exposure during pregnancy causes a recognized pattern of major congenital malformations (warfarin embryopathy and fetotoxicity), fatal fetal hemorrhage, and coumadin vitamin k what is coumadin level coumadin side effects skin coumadin withdrawal how do you an increased risk of spontaneous abortion and fetal mortality .
If this drug is used during pregnancy, or if the patient becomes coumadin pregnant while taking this drug, the patient should be apprised of the potential hazard to a fetus [see Use in Specific Populations (8 .

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