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2019-06-25 at 03:22PM UTC #280791
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Pantoprazole was positive in the in vitro human lymphocyte chromosomal aberration assays, in one of two mouse micronucleus tests for clastogenic effects, and is protonix an antacid protonix warnings pfizer protonix lawsuit protonix 400 mg protonix for gerd in the in vitro Chinese hamster ovarian cell/HGPRT forward mutation assay for mutagenic effects .
Equivocal results were observed in the in protonix vivo rat liver DNA covalent binding assay .
Pantoprazole was negative in the in vitro Ames mutation assay, the in vitro unscheduled DNA synthesis (UDS) assay with rat hepatocytes, the in vitro AS52/GPT mammalian cell-forward gene mutation assay, the in vitro thymidine protonix kinase mutation test with mouse lymphoma L5178Y cells, and the in vivo rat bone marrow cell chromosomal aberration assay .
A 26-week p53 +/- transgenic mouse carcinogenicity study was not protonix 20 mg side effects protonix substitute protonix directions what drug class is protonix positive .
Pantoprazole at oral doses up to 500 mg/kg/day in male rats (98 times the recommended human dose based on body surface area) and 450 mg/kg/day in female rats (88 times the recommended human dose based on body surface area) was found to have no effect on fertility protonix and reproductive performance .
Teratogenic Effects Pregnancy Category B Teratology studies have been performed in rats at intravenous doses up to 20 mg/kg/day (4 times the recommended human dose based on body surface area) and rabbits at intravenous doses up to 15 mg/kg/day (6 times the recommended human dose based on body surface area) and have revealed no evidence of impaired fertility or protonix harm to the fetus due to pantoprazole .
There are, however, no adequate and well-controlled studies in protonix pregnant women .

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