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tapentadol therapeutic category tapentadol tablets tapentadol droge tapentadol tabletten tapentadol Four studies provided pivotal efficacy data .
These were randomised, double-blind, active and placebo-controlled studies in patients following bunionectomy tapentadol (Studies KF5503/32 and KF5503/37), abdominal hysterectomy (Study KF5503/35) and end- stage degenerative joint disease of the hip or knee (Study KF5503/33) .
The active tapentadol comparators were oxycodone IR (Studies KF5503/32 and KF5503/33) and morphine IR (Studies KF5503/35 and KF5503/37) .
These studies used tapentadol a fixed dose of tapentadol with flexible administration of every 4 to 6 The primary efficacy variable was the Sum of Pain Intensity Difference (SPID) .
The Pain Intensity Difference (PID) tapentadol was the difference between baseline pain intensity and current pain intensity .
SPID was defined as Σ Wi x PIDi where the sum included all observations of PID collected from baseline tapentadol fibromyalgia nucynta company tapentadol uso palexia pronounce nucynta erowid nucynta high to specific fixed time-points and Wi is the time elapsed from the previous observation .
Higher SPID tapentadol indicated greater pain relief .
The primary time-point for analysis of efficacy was 48 hours from commencement of study treatment in Studies 32 and 37, 24 hours from commencement in Study 35 tapentadol and at Day-5 in Study 33 .
AusPAR Palexia IR Tapentadol CSL Pty Ltd PM-2009-02488-3-1 Date of palexia sr tablets tapentadol recreational tapentadol estructura quimica tapentadol plm tapentadol Finalisation 17 November 2010 Therapeutic Goods Administration All these studies showed statistically significant superior efficacy compared with placebo for their primary endpoint .

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