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2019-06-25 at 10:25AM UTC #280773
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The design topamax of both trials (one study was conducted in the U .
and one topamax and alcohol interaction benefits of topamax topamax and kidney damage how to treat insomnia study was conducted in the U .
and Canada) was identical, enrolling patients with a history of migraine, with or topamax reviews for depression topamax depression topamax eye side effects migraine medication without aura, for at least 6 months, according to the International Headache Society diagnostic criteria .
Patients with a history of cluster headaches or basilar, ophthalmoplegic, hemiplegic, or transformed migraine headaches were excluded topamax eye pain how long is topamax in your system topamax eye pressure topamax and mood swings from the trials .
Patients were topamax required to have completed up to a 2-week washout of any prior migraine preventive medications before starting the baseline phase .
Patients who experienced 3 topamax to 12 migraine headaches over the 4 weeks in the baseline phase were equally randomized to either TOPAMAX® 50 mg/day, 100 mg/day, 200 mg/day, or placebo and treated for a total of 26 weeks (8-week titration period and 18-week maintenance Reference ID: 3197087 NDA 020505-S-050 Topamax (topiramate) oral tablets (25mg, 50mg, 100mg and 200mg) NDA 020844-S-041 Topamax (topiramate) sprinkle capsules (15mg, and 25mg) FDA Approved Labeling Text dated September 2012 period) .
Treatment was initiated at 25 mg/day for one week, and then the daily dosage was increased by 25 mg increments each week until reaching the topamax assigned target dose or maximum tolerated dose (administered twice daily) .
Effectiveness of treatment was assessed by the reduction in migraine headache frequency, as measured by the change in 4-week migraine rate from the baseline phase to double-blind topamax treatment period in each TOPAMAX® treatment group compared to placebo in the Intent-ToTreat (ITT) population .

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